The overarching goal of the EpiChildCan project is to understand the underlying molecular causes of cancers in children and adolescents by investigating epigenetic changes driven by risk factors and identifying epigenetic markers for cancer risk stratification and early detection. The hypothesis is that epigenome changes associated with risk of childhood cancer and exposure to environmental, dietary, and lifestyle factors during pregnancy can be identified in blood cells at birth, and that these methylation changes can serve as sensitive biomarkers in primary and secondary prevention as well as targeted therapy of childhood cancer.